Mitoxantrones for Cancer Treatment and there Side Effects

Mitoxantrone is an anticancer drug which is mostly used for the treatment of breast cancer and non-Hodgkin’s lymphoma. Its structure is related to anthracycline. There are only few methods available for its synthesis. It is synthesized to reduce the cytotoxic effects of anthracycline derivatives. There are more than fifteen analogues of mitoxantroneon the basis of different groups attached at positions 1 to 4. It is an inhibitor of DNA-topoisomerase II, but its exact mode of action is unknown. The spectral elucidation and elevation of melting temperature technique are used to study DNAbinding properties of mitoxantrone. The major adverse effects of mitoxantrone usage arecardiotoxcityand effecting the electron transport chain in mitochondria. Efforts are required to synthesize better analogues of mitoxantrone that posses cancer cell specific cytotoxicity.